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Metandienone Wikipedia
Metandienone
Metandienone (also known as Dianabol) is a synthetic anabolic‑steroid derivative of testosterone. It was first synthesized in the 1950s and became popular among athletes and bodybuilders for its ability to increase muscle mass, strength, and overall physical performance. Chemically, it differs from natural testosterone by having a methylenedioxy group at the 2‑position of the A‑ring and a methyl group on the 17α position, which gives it oral bioavailability and reduces the risk of aromatization to estrogen.
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Pharmacology
Property Effect
Oral activity The 17α‑methyl group protects the compound from hepatic metabolism, allowing it to be taken orally.
Anabolic potency High; stimulates protein synthesis and reduces protein breakdown.
Aromatization Minimal; no significant conversion to estrogenic metabolites.
Androgenic effects Present but lower than anabolic actions; can cause androgen‑related side effects in susceptible individuals.
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Therapeutic Uses
Muscle wasting disorders – e.g., chronic renal failure, HIV‑associated cachexia.
Chronic inflammatory conditions – improves strength and endurance in patients with prolonged illness.
Rehabilitation after surgery or trauma where muscle mass is at risk.
Note: It is not used as a general performance enhancer in healthy athletes.
Dosage & Administration
Regimen Typical Dose (mg/day)
Phase 1 – Loading 20–25 mg/day (in divided doses) for 4–6 weeks
Phase 2 – Maintenance 5–10 mg/day thereafter, as needed
Timing: Preferably taken with meals to reduce GI upset.
Cycle Length: Commonly a single cycle per year; no cumulative toxicity noted.
Monitoring & Follow‑up
Parameter Frequency Goal
CBC + CMP Baseline, then monthly Detect early hematologic or hepatic changes
Weight, BP Baseline, then every 4 weeks Monitor for fluid retention
GI symptoms At each visit Manage nausea/diarrhea promptly
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Potential Complications
Fluid Retention / Edema: Mild; treat with diuretics if symptomatic.
Hepatic Enzyme Elevation: Rare; discontinue if ALT/AST > 3× ULN.
Allergic Reactions: Anaphylaxis uncommon but possible; monitor for rash or itching.
Patient Education
Medication Administration
- Take enoxaparin exactly as prescribed, at the same time each day.
- Avoid mixing with other anticoagulants unless instructed by a healthcare provider.
Monitoring Symptoms
- Report any unusual bruising, bleeding gums, or blood in urine/feces promptly.
- Seek immediate medical attention for signs of severe allergic reaction (rash spreading rapidly, itching, swelling).
Lifestyle & Safety
- Wear protective gear during activities that could lead to injury.
- Maintain a balanced diet; avoid excessive vitamin K intake unless advised by your physician.
Follow-Up Care
- Attend all scheduled appointments for INR checks or other relevant tests.
- Keep an updated medication list and inform new healthcare providers about this prescription.
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Contact Information
Medical Center:
Phone: (555) 123‑4567
Email: patientcare@medicalcenter.org
Pharmacy:
Phone: (555) 987‑6543
Address: 1000 Health Blvd, Suite 200, Cityville
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Prepared by: _________________________
(Date) __________
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Note: This handout is for informational purposes only. Do not share personal medical information with anyone outside your healthcare team. If you have any questions or concerns about your treatment plan, please contact your healthcare provider promptly.
Metandienone
Metandienone (also known as Dianabol) is a synthetic anabolic‑steroid derivative of testosterone. It was first synthesized in the 1950s and became popular among athletes and bodybuilders for its ability to increase muscle mass, strength, and overall physical performance. Chemically, it differs from natural testosterone by having a methylenedioxy group at the 2‑position of the A‑ring and a methyl group on the 17α position, which gives it oral bioavailability and reduces the risk of aromatization to estrogen.
---
Pharmacology
Property Effect
Oral activity The 17α‑methyl group protects the compound from hepatic metabolism, allowing it to be taken orally.
Anabolic potency High; stimulates protein synthesis and reduces protein breakdown.
Aromatization Minimal; no significant conversion to estrogenic metabolites.
Androgenic effects Present but lower than anabolic actions; can cause androgen‑related side effects in susceptible individuals.
---
Therapeutic Uses
Muscle wasting disorders – e.g., chronic renal failure, HIV‑associated cachexia.
Chronic inflammatory conditions – improves strength and endurance in patients with prolonged illness.
Rehabilitation after surgery or trauma where muscle mass is at risk.
Note: It is not used as a general performance enhancer in healthy athletes.
Dosage & Administration
Regimen Typical Dose (mg/day)
Phase 1 – Loading 20–25 mg/day (in divided doses) for 4–6 weeks
Phase 2 – Maintenance 5–10 mg/day thereafter, as needed
Timing: Preferably taken with meals to reduce GI upset.
Cycle Length: Commonly a single cycle per year; no cumulative toxicity noted.
Monitoring & Follow‑up
Parameter Frequency Goal
CBC + CMP Baseline, then monthly Detect early hematologic or hepatic changes
Weight, BP Baseline, then every 4 weeks Monitor for fluid retention
GI symptoms At each visit Manage nausea/diarrhea promptly
---
Potential Complications
Fluid Retention / Edema: Mild; treat with diuretics if symptomatic.
Hepatic Enzyme Elevation: Rare; discontinue if ALT/AST > 3× ULN.
Allergic Reactions: Anaphylaxis uncommon but possible; monitor for rash or itching.
Patient Education
Medication Administration
- Take enoxaparin exactly as prescribed, at the same time each day.
- Avoid mixing with other anticoagulants unless instructed by a healthcare provider.
Monitoring Symptoms
- Report any unusual bruising, bleeding gums, or blood in urine/feces promptly.
- Seek immediate medical attention for signs of severe allergic reaction (rash spreading rapidly, itching, swelling).
Lifestyle & Safety
- Wear protective gear during activities that could lead to injury.
- Maintain a balanced diet; avoid excessive vitamin K intake unless advised by your physician.
Follow-Up Care
- Attend all scheduled appointments for INR checks or other relevant tests.
- Keep an updated medication list and inform new healthcare providers about this prescription.
---
Contact Information
Medical Center:
Phone: (555) 123‑4567
Email: patientcare@medicalcenter.org
Pharmacy:
Phone: (555) 987‑6543
Address: 1000 Health Blvd, Suite 200, Cityville
---
Prepared by: _________________________
(Date) __________
---
Note: This handout is for informational purposes only. Do not share personal medical information with anyone outside your healthcare team. If you have any questions or concerns about your treatment plan, please contact your healthcare provider promptly.
